The T2T consortium was formed in 2018 as an open, community-based effort to generate the first complete sequence of a human genome. In 2022, we published the first genome to be completely sequenced from end to end, T2T-CHM13, which revealed over 200 Mbp of novel sequence, including satellite arrays and segmental duplications that harbor unexplored variation of unknown consequence. It made international headlines, but for us it was only the beginning.
Our new goal is to dramatically increase the throughput of diploid T2T genome sequencing so that we can develop a better understanding of genomic code, for the improvement of human health and wellbeing.
Our annual T2T-F2F (Face-to-Face) conference will be held on September 3-4, 2026 in Santa Cruz, CA. Join us for two exciting days of networking, and discussions on groundbreaking T2T-genomics projects and new epigenetic initiatives.
Registration for this year's conference is currently closed.
The T2T consortium is working with the Human Pangenome Reference Consortium on a new, usable reference for genomics that will eventually combine the genetic material of hundreds of individuals from different ancestral backgrounds.
Watch this explainer video from UC Santa Cruz to learn why one T2T sequence was not enough, and how a new reference will to allow for a deeper, more accurate understanding of worldwide genomic diversity
T2T has published a full reference of the notoriously difficult-to-sequence Y chromosome to complete the T2T set! Read more.
Watch the NHGRI's animation on why it took so long to fully sequence the human genome.
Hear about what this accomplishment means from T2T Consortium co-lead Karen Miga.
Watch the NHGRI's animation explaining the Human Pangenome Project, learn how the T2T project fits into this ambitious initiative.
